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Chemosensitivity 1

GDF15 1

Gemcitabine 1

Intrahepatic cholangiocarcinoma 1

Peripheral blood mononuclear cells 1

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cellular metabolism 1

chemoresistance 1

esophageal squamous cell carcinoma 1

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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 157-160 doi: 10.1007/s11684-007-0029-z

Abstract: This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directedThis tissue was put through the assay to determine chemosensitivity.
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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistance. Growth differentiation factor 15 (GDF15) is crucial in the development of various types of tumors and negatively related to the prognosis of ESCC patients according to our previous research. In this study, the link between GDF15 and chemotherapy resistance in ESCC was further explored. The relationship between GDF15 and the chemotherapy response was investigated through in vitro and in vivo studies. ESCC patients with high levels of GDF15 expression showed an inferior chemotherapeutic response. GDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation via TGFBR2. Through an in vivo study, we further validated that the anti-GDF15 antibody improved the tumor inhibition effect of cisplatin. Metabolomics showed that GDF15 could alter cellular metabolism and enhance the expression of UGT1A. AKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A, indicating that TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to cisplatin. The present investigation suggests that a high level of GDF15 expression leads to ESCC chemoresistance and that GDF15 can be targeted during chemotherapy, resulting in beneficial therapeutic outcomes.

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Article

Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1381-1393 doi: 10.1016/j.eng.2021.01.014

Abstract: Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but chemosensitivity varies

Keywords： Intrahepatic cholangiocarcinoma     Gemcitabine     Chemosensitivity     Peripheral blood mononuclear cells    

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Title Author Date Type Operation

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article

Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma

Tong Wu, Ying-Cheng Yang, Bo Zheng, Xue-Bing Shi, Wei Li, Wen-Cong Ma, Shan Wang, Zhi-Xuan Li, Yan-Jing Zhu, Jian-Min Wu, Kai-Ting Wang, Yan Zhao, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Lei Chen, Zhen-Gang Yuan, Hong-Yang Wang

Journal Article